Giulia KennedyPhD
Proceedings of the National Academy of Sciences of the United States of America · 1992

Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells

G C Kennedy, W J Rutter

First authorstrongly supportedGene regulation and gene discovery
Journal
Proceedings of the National Academy of Sciences of the United States of America · vol. 89 · no. 23
Published
1 Dec 1992

Synopsis

Isolated a cDNA encoding Pur-1, a zinc-finger protein that binds the GAGA boxes of the rat insulin I and II genes and the human islet amyloid polypeptide gene. Pur-1 is a potent transactivator in both pancreatic and non-pancreatic cells and can activate an intact insulin promoter in HeLa cells, where it is normally inactive. Her principal postdoctoral paper on insulin gene regulation, from the Rutter laboratory at UCSF.

In the career genome

  • UCSFChapter 01 · Strand A · Institution
    University of California, San Francisco

    Education and training

    B.S. Applied Science; Ph.D. Biochemistry; postdoctoral training in biochemistry

    1992 – 1995